Family Ties

genes

I’ve been thinking about family a lot lately.

A week ago I got the news that I tested positive for the BRCA2 gene mutation, also known as the “breast cancer gene.” This name is a bit deceiving, as this gene (along with the BRCA1 gene) is linked to a number of cancers, including ovarian, pancreatic and prostate. Everyone has these genes. And when they work correctly (i.e. do not have a mutation), they act as tumor suppressors, essentially keeping our own cells from going haywire and growing out of control, causing cancer.

Not realizing there was more to this “breast cancer gene” than breast cancer, I was honestly totally surprised to have tested positive for it because no one I knew of in my family had been diagnosed with breast cancer. I shouldn’t have been. Both my maternal grandmother and great-grandfather had pancreatic cancer (among other types). While I remember my grandmother finally succumbing to the effects of liver cancer, that was not where her disease initially began (especially since liver cancer is generally a secondary cancer, having spread from elsewhere in the body).

12472449_10154098880459314_2015776637288938079_n

Me, my mom and my sister in the ’80s.

My mom died 16 years ago in a car accident at the age of 53. I think she always sort of felt like she would end up getting cancer (both her parents died of it; my grandfather had melanoma and lung cancer). Since there is pretty much no history of cancer on my dad’s side of the family, it’s almost certain I inherited this mutation from her, and she from her own mother. Knowing what I know now, I’m pretty sure she would have developed cancer in some form by this point, had she lived. Sometimes I almost feel grateful that she was spared that and died instantly and painlessly.

Being that I lost my mom and both my maternal grandparents relatively early (I was 7 when my grandmother died, 12 when my grandfather died and 21 when my mom died), and I have so few relatives left on that side of the family (just an aunt, uncle and my sister), I’ve always felt like that part of my family is sort of an enigma. I have lots of questions and so few people to answer them. I wish I’d had the forethought to ask my mom things before she died, but I was so young and wrapped up in my own life that those sorts of things never really came up.

My sister is going to be tested for the gene mutation. One day, my son will, as well. I’ve notified my uncle, so if he wants to, he can get testing, too, as can my aunt. I hope and pray none of them have it. There’s a 50/50 chance that they did not inherit it (each gene has two parts, one from the mother and one from the father, so my grandmother could have passed along the good side from her mother, and my mother the good side from her father).

Knowledge is power, especially when it comes to fighting cancer. I am grateful to have this knowledge on my side. But, it has changed the way I look at my family. I feel like we’re all marked, cursed in a way, passing this dreadful disease down through the generations. My only hope is that I’m the last one.

Advertisements

2 thoughts on “Family Ties

  1. Jennifer, I will be reading your blog… definitely from the heart, educational, and well written! I have felt “lucky and blessed” to have such a negative cancer history on mom’s (aunt Chris’s) side…your words remind me that the gene can touch us in many ways. Then there is the environmental stuff…scary world. All the more reason to say “come Lord Jesus”.

    Like

  2. Pingback: Mastectomy, Simple, Complete | Two Boobs, One Fight

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s